PC12相关论文
神经元是神经系统最基础的功能单元,由胞体（soma）和突起（neurite）两部分组成（突起又称为神经纤维,分为轴突（axon）和树突（dendrite）两种）,有感......
目的:探索经β-NGF诱导后的PC12细胞机械损伤后内质网应激与PI3K/AKT/m TOR信号通路介导自噬之间的关系。研究内容:脊髓损伤一般会......
背景:缺血性脑卒中（Ischemic stroke）是最常见的卒中类型,发生在颈部或大脑血管阻塞时,严重威胁着人类的健康,特别是围手术期急性缺......
PC12作为模式细胞已被广泛应用于多种疾病研究.为探究高效、低毒的PC12的细胞转染方法,试验采用化学转染法,以带有5′-羧基荧光素(......
Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Ne
Patients with diabetes mellitus have a higher risk of developing Parkinson\'s disease (PD).However,the molecular links......
The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymu......
Background and Purpose:Nerve regeneration and functional recovery are major issues following nerve tissue damage....
Heat shock protein A12B (HSPA12B) is the newest member of a recently defined subfamily of proteins distantly related to ......
APE/Ref-1 mediates the prevention of 5-HMF against oxidative injury caused by brain ischemia in rats
Cerebral ischemia-reperfusion injury plays an important role in the evolution of brain damage through mechanisms that in......
目的 观察当归提取物AS-A、AS-B、AS-C、AS-D、AS-E、AS-F、AS-G和AS-B-1对PC12细胞生长分化的影响和对PC12细胞缺氧损伤的保护作......
Aim: The aim of this paper is to investigate the protective effects of recombinant Lampetra Japonica RGD-peptide (rLj-RG......
Disturbances in K+ homeostasis have been implicated in a variety of neuropathological including Parkinsons disease (PD).......
Autophagy is a natural process of self-eating that occurs within cells and can be either pro-survival or can cause cell ......
目的 观察氟西汀对皮质酮诱导的PC12细胞损伤的保护作用。研究氟西汀对皮质酮诱导的PC12细胞损伤过程中FoxO3a、Akt蛋白磷酸化表达......
Effects of Astragaloside Ⅳ combined with Ginsenoside Rg1 on autophagy and PI3K signaling pathways of
AIM: To probe the effects and the mechanism of Astragaloside Ⅳ and Ginsenoside Rg1 on autophagy of PC12 cell induced by......
Acetylated chitosan oligosaccharides act as antagonists against glutamate-induced PC12 cell death vi
Chitosan oligosaccharides (COSs), depolymerized products of chitosan composed of β-(1→4) D-glucosamine units, have bro......
Novel structure compounds (WS) containing 3,4,5-trimethoxyphenyl and acyl pyrazole were designed and synthesized based c......
会议
The present study examined the effects of Tremella fuciformis (TF) on the learning and memory function and the neural ac......
The Nmda Receptor Signaling Pathway Mediated Synaptic Plasticity Injuryin Rat Hippocampusand PC12 Ce
Background: Microwave exposure has multipleadverse effects on the nervous system resulting in various cognitive and beha......
Parkinsons disease (PD) is the second most common neurodegenerative disease and afflicts almost 1.8％ of over 65-year-old ......
miRNAs are short noncoding RNA molecules that downregulate gene expression at post-transcriptional level.miRNAs are post......
目的 探讨谷氨酸诱导PC12细胞凋亡后磷酸化蛋白酪氨酸激酶2(P-JAK2)、磷酸化信号转导子与转录激活子3(P-STAT3)表达的变化及意义. ......
[目的]研究泽兰提取物对低糖低氧所致神经细胞损伤的影响及潜在分子机制.[方法]用PC12细胞建立脑缺血模型,然后用0.1、1、10 mg/mL......
目的探讨促红细胞生成素(erythropoietin,EPO)对1-甲基-4-苯基吡啶离子(MPP+)诱导的PC12细胞变性损伤的保护作用及机制。方法用MPP......
目的考察芍药内酯苷对1-甲基-4-苯基吡啶离子(MPP+)诱导的PC12细胞损伤的保护作用及分子机制。方法 4mmol·L-1MPP+处理大鼠嗜铬细......
目的:探讨高良姜素对H_2O_2诱导的PC12细胞氧化损伤的保护作用及其作用机制。方法:用H_2O_2损伤PC12细胞建立氧化应激损伤模型,细......
目的探讨哈巴苷对β淀粉样蛋白(Aβ_(25-35))诱导的PC12细胞毒性的影响。方法 PC12细胞以哈巴苷(20、40、80μmol/L)预孵育3 h后以......
目的研究不同浓度氯化镉对鼠肾上腺嗜铬细胞瘤细胞(PC12)增值和神经生长因子(NGF)诱导下PC12细胞分化的影响。方法①采用MTT比色微......
目的 探讨 RNA-18a在脑梗死中的作用.方法 在糖氧剥夺后通过 qRT-PCR方法分析 miR-1 8a的表达水平,通过 Western blot 和 qRT-PCR......
背景:药物治疗阿尔茨海默病难以达到满意效果,而多项研究表明,骨髓间质干细胞移植治疗帕金森病、脑缺血等有效,但其治疗机制尚不十......
期刊
目的 观察丙泊酚与利血平单用或合用对缺血/缺氧及再灌注致中枢神经元细胞损伤的保护作用及其可能机制.方法 用大鼠肾上腺嗜铬细胞......
Cytotoxicity evaluation of extracts and fractions of ifve marine sponges from the Persian Gulf and H
Objective:To screen the cytotoxic effects of some marine sponges extracts on HeLa and PC12 cells.
Methods: Five marine......
目的探讨雷沙吉兰(Rasagiline)对β-淀粉样蛋白(Aβ)诱导PC12细胞损伤阿尔茨海默病(AD)模型的保护作用及其机制.方法不同浓度的Aβ......
目的 探讨神经毒素6-羟基多巴胺(6-OHDA)诱导PC12细胞的帕金森(PD)模型中GRP78的表达.方法 在建立6-OHDA诱导PC12细胞帕金森模型的......
目的: 构建GAP-43小干扰RNA(SiRNA)的表达载体并在大鼠嗜铬细胞瘤细胞系PC12中验证其抑制效果.方法: 利用设计软件根据GAP-43 mRNA......
目的探讨Transferrin在小鼠脑缺血再灌注模型中的表达及意义。方法取8周龄C57BL/6J野生型雄性小鼠12只,按随机数字表法分为假手术......
目的:探讨XXM及其相关单体成分KAE对慢性缺血缺氧引起的脑损伤的作用及其机制。方法:采用双侧颈总动脉永久性结扎(bilateral commo......
目的:中暑是一种严重的热性疾病,主要表现为体温过高与中枢神经系统功能障碍,严重的中暑可导致多脏器功能衰竭,具有较高的死亡率与......
学位
目的:探讨在氧糖剥夺再灌注后CDK1对GRASP65及高尔基体形态的影响。方法:1.建立氧糖剥夺再灌注(OGD/R)细胞模型;2.实验分为正常对......
目的:探讨黄连素(Berberine,BBR)对氧糖剥夺/复氧(Oxygen Glucose Deprivation/reoxygenation,OGD/R)模拟的缺血再灌注所致PC12细......
The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via
Salidroside (SAL),a major bioactive compound of Rhodiola crenulata,has significant anti-hypoxia effect,however,its under......
脊髓损伤(spinal cord injury,SCI)是脊柱损伤最严重的并发症,往往导致损伤节段以下严重的功能障碍。SCI具有较高的致残率及致死率......
帕金森病(Parkinson’s disease,PD)是发生于中枢神经系统常见的退行性疾病。目前认为PD的主要病因可能是遗传变异、环境因素、氧......
背景神经元增殖和分化障碍影响创伤性中枢神经系统损伤后的修复和再生,进一步会产生各种各样的神经系统疾病。前期实验结果证明PTE......
目的:1.探究LPA诱导神经元样PC12细胞凋亡的分子机制。2.探究LPA受体(LPA1和LPA2)和MAPK通路(ERK1/2、p38和JNK)在LPA诱导的神经元......
中枢神经系统(Central nervous system,CNS)轴突损伤是神经退行性疾病的主要诱因之一,临床上症状主要有记忆力衰退,主要相关疾病有......
